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Why Choose BONTAC?
Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
Unlocking the Secrets of NMN: Mechanism and Effects on Health
In the world of cutting-edge biotechnology, few compounds have garnered as much attention as Nicotinamide Mononucleotide, or NMN. This revolutionary molecule is taking the health and wellness industry by storm, and for a good reason. In this article, we will explore what NMN is, its mechanisms, and its profound effects on health.
What is NMN?
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound found in all living cells. It plays a crucial role in the production of Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme that is essential for various biological processes in the body. NAD+ levels tend to decline as we age, contributing to various age-related health issues. NMN supplementation aims to boost NAD+ levels, potentially reversing or mitigating these issues.
The Mechanism: How NMN Works
NMN is a precursor to NAD+, meaning it is converted into NAD+ in our cells. This transformation is vital because NAD+ is involved in several critical cellular functions, including energy metabolism, DNA repair, and gene expression. When NMN is administered, it enhances the NAD+ levels, providing the body with more of this essential coenzyme.
Effects of NMN on Health
The increased availability of NAD+ through NMN supplementation has far-reaching effects on health and wellness:
1、Energy Production: NAD+ is a key player in the production of adenosine triphosphate (ATP), the body's primary energy currency. More NAD+ means more energy for the body's cells, potentially leading to increased vitality and stamina.
2、Cellular Repair: NAD+ supports DNA repair mechanisms, helping to maintain the integrity of the genome. This is crucial in preventing mutations that can lead to aging and the development of diseases.
3、Sirtuin Activation: NAD+ is necessary for the activation of sirtuins, a family of proteins that regulate cellular health. Sirtuins have been associated with longevity and can help combat age-related issues.
4、Metabolic Health: Increased NAD+ levels can have a positive impact on metabolic processes, potentially aiding in weight management and preventing metabolic disorders.
5、Neuroprotection: Some studies suggest that NAD+ augmentation with NMN may help protect against neurodegenerative diseases like Alzheimer's and Parkinson's.
6、Cardiovascular Health: NAD+ plays a role in maintaining healthy blood vessels, which can contribute to cardiovascular health.
7、Immune System Support: NAD+ helps regulate the immune system, potentially enhancing its ability to respond to infections and diseases.
Is NMN Safe?
NMN is generally considered safe for use, and it has been extensively studied in animal models. However, more research is needed to fully understand its long-term effects in humans. As with any supplement, it's crucial to consult with a healthcare professional before incorporating NMN into your health regimen.
In conclusion, NMN is a remarkable compound with the potential to revolutionize health and wellness. By increasing NAD+ levels, NMN supplementation can positively impact energy levels, cellular repair, metabolic health, and more. As the biotechnology industry continues to explore the possibilities of NMN, it may become a key player in the quest for longevity and enhanced well-being.
At Bontac, we are at the forefront of providing high-quality NMN raw materials for businesses in the health and wellness industry. Our commitment to quality and innovation ensures that our partners can harness the full potential of NMN. Contact us to learn more about our NMN offerings and how we can assist your business in delivering cutting-edge products to the market.
NMN: Manufacturing, Preparation, and Clinical Trials
In the realm of cutting-edge biotechnology, one compound has taken center stage for its potential to transform the landscape of health and wellness. Nicotinamide Mononucleotide (NMN) has been the subject of significant research, with a focus on its manufacturing and preparation processes, as well as its clinical trials.
NMN Manufacturing and Preparation
NMN is a derivative of niacin (vitamin B3) and is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme involved in various cellular functions. Producing NMN involves several steps to ensure its purity and effectiveness:
1、Extraction: NMN can be synthesized from niacin or obtained through the extraction of natural sources like milk. These sources contain precursors that can be converted into NMN.
2、Purification: After extraction, NMN must undergo purification processes to remove impurities and achieve the desired level of purity. High purity is essential to ensure the efficacy and safety of NMN supplements.
3、Synthesis: Chemical synthesis is another method for manufacturing NMN. This involves converting niacin into NMN through a series of chemical reactions. This method offers precise control over the NMN production process.
4、Quality Control: Throughout the manufacturing process, rigorous quality control measures are applied to guarantee the safety and effectiveness of the final product. These measures include testing for purity, potency, and absence of contaminants.
The manufacturing and preparation of NMN require careful attention to detail to ensure that the end product meets the highest standards for quality and safety.
NMN Clinical Trials
Clinical trials related to NMN have provided valuable insights into its potential benefits. These trials have explored various aspects of NMN supplementation, shedding light on its safety and effectiveness:
1、Aging and Longevity: Some studies have suggested that NMN supplementation may have a positive impact on aging-related issues, potentially extending lifespan and improving overall health.
2、Metabolic Health: Clinical trials have examined the effects of NMN on metabolic health. Preliminary results have indicated potential benefits in areas such as glucose metabolism and insulin sensitivity.
3、Cardiovascular Health: Research has investigated the impact of NMN on cardiovascular health. Promising findings have emerged regarding blood vessel function and blood pressure regulation.
4、Neuroprotection: NMN's potential neuroprotective properties have been studied in the context of neurodegenerative diseases. While more research is needed, early results have been encouraging.
5、Safety and Tolerability: Clinical trials have also focused on the safety and tolerability of NMN. Generally, NMN has been well-tolerated, with few reported side effects.
It's important to note that while these clinical trials have provided valuable data, the research on NMN is ongoing, and more extensive studies are needed to establish its long-term safety and efficacy.
Bontac, a leading biotech enterprise, is at the forefront of providing high-quality NMN raw materials. Our commitment to innovation and quality ensures that our partners can develop products that meet the highest standards in the health and wellness industry. With a strong emphasis on research and development, we aim to contribute to the ongoing exploration of NMN's potential benefits.
In conclusion, NMN manufacturing and preparation involve a series of rigorous steps to ensure the production of high-quality, safe supplements. Clinical trials have provided promising insights into NMN's potential benefits in areas such as aging, metabolic health, cardiovascular health, and neuroprotection. As research on NMN continues, Bontac remains dedicated to providing the industry with the finest NMN raw materials for the development of innovative health and wellness products.
Best NMN Powder: Factory, Purity, and Supplier
When searching for the best NMN (Nicotinamide Mononucleotide) powder, three key aspects play a pivotal role in your decision-making process. This comprehensive guide dives into the world of NMN, highlighting the critical factors that set the best NMN powder apart. We'll explore the best NMN powder factory, delve into the significance of purity, and introduce you to a reliable NMN powder supplier.
- Best NMN Powder Factory :
- State-of-the-Art Manufacturing:
The foundation of premium NMN powder begins at the factory. Look for a manufacturer that boasts state-of-the-art facilities, adhering to the highest standards of production. Top-tier factories utilize cutting-edge technology and rigorous quality control to ensure the finest NMN powder.
- Research and Development:
Leading NMN powder factories invest in robust research and development. They actively engage in scientific studies and collaborate with experts to continuously enhance their product's quality and effectiveness.
- Quality Certifications:
Reputable factories hold certifications such as GMP (Good Manufacturing Practices) and ISO, underscoring their commitment to quality, safety, and consistency. These certifications are a testament to their dedication to producing the best NMN powder.
- Best NMN Powder Purity (approx. 200 words):
- High Purity Standards:
The purity of NMN powder is paramount. Opt for a product with a purity rating of 99% or higher. The best NMN powder is free from impurities and excipients, ensuring maximum potency.
- Independent Testing:
To validate purity claims, the best NMN powder undergoes independent third-party testing. These tests provide transparency and assurance that what you're purchasing aligns with its purity claims.
- No Additives or Fillers:
A top-quality NMN powder doesn't contain additives or fillers. The absence of unnecessary substances ensures you're receiving a pure and potent product.
- Best NMN Powder Supplier:
- Reliability and Reputation:
Selecting the right supplier is crucial. Look for a supplier with a stellar reputation for delivering consistent, high-quality NMN powder. Online reviews and testimonials can offer insights into their reliability.
- Transparent Sourcing:
A trustworthy supplier should be transparent about the sourcing and production of their NMN powder. Clear information about their supply chain and production process demonstrates their commitment to quality.
- Customer Support:
The best NMN powder supplier offers excellent customer support. Whether you have questions or need assistance, a responsive and knowledgeable support team is a valuable asset.
In the quest for the best NMN powder, the factory, purity, and supplier are non-negotiable elements. By opting for a manufacturer with cutting-edge facilities, a commitment to purity, and a reliable supplier with a sterling reputation, you'll embark on a journey towards reaping the full benefits of NMN. The best NMN powder is not just a product; it's a commitment to your well-being.
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A Promising Intestinal Health Protector: NMN
1. Introduction Nicotinamide Mononucleotide (NMN) has been deemed as a functional nutrient for improving human intestinal health. In this study, an in vitro simulated digestion model is established under salivary and gastrointestinal conditions to determine the digestive properties of NMN, followed by the track of subsequent fermentation and its effect on the intestinal microbiota. 2. The digestion and fermentation of NMN No significant change is discernible in the molecular weight of NMN under salivary and gastrointestinal conditions. The hydrolysis rates of NMN to nicotinamide (NAM) in saliva, gastric juice and intestinal fluid are 3.0%, 1.9% and 4.2%, respectively, signifying that NMN can reach the colon without apparent difficulty. Post 24-h fermentation, NMN boosts the accumulation of propionate and butyrate by 88 % and 23 %, respectively, enhancing the abundance of beneficial genera (Bifidobacterium, Phascolarctobacterium, Faecalibacterium and Alistipes) and repressing proliferation of some harmful bacteria (Sutterella, Desulfovibrio and Pseudomonas) in human intestinal microbiota. 3. The intestine metabolic pathway of NMN Prior to being absorbed by the human body, NMN should be first transformed into nicotinamide ribose (NR), then degraded to NAM and converted to niacinate (NA). Concretely, intestinal microbiome degraded into various fermentation products such as NR, NAM, NA, etc., which are absorbed and utilized as nutrients by the intestinal microbiome. 4. The role of SCFAs in intestinal tract Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are the major products of carbohydrate fermentation in the colon, which can maintain normal gut function, bolster the absorption of sodium and calcium, promote digestion, facilitate the healing of injured intestinal mucosa, and prevent ulcers and enteritis. 5. The relationship between NMN, intestinal microbiota, and SCFAs NMN and its catabolism intermediates function as a carbon source for the proliferation of intestinal microbes during the in vitro NMN fermentation by human intestinal microbes. The low level of branched SCFAs in the NMN group is due to the breakdown of NMN by microorganisms into a variety of carbohydrates, including NAM and ribose. 6. Conclusion In addition to modulating the fermentation metabolites, NMN can regulate microbiota composition by promoting the proliferation of beneficial genera, providing a potent guarantee and support for intestinal health. Reference Tang Z, Bao P, Ling X, Qiu Z, Zhang B, Hao T. In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation of nicotinamide mononucleotide, and its effects on the gut microbiota. Food Res Int. 2024;177:113779. doi:10.1016/j.foodres.2023.113779 About BONTAC BONTAC has dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 160 global patents as well as strong R&D team consisting of Doctors and Masters. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NMN. High quality and stable supply of products can be better ensured here with the exclusive Bonpure seven-step purification technology and Bonzyme Whole-enzymatic method. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
The Significance of NAD+ in Intestinal Senescence Caused by Elevated mtDNA Mutations
1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis and the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to NAD+ depletion and activate the transcription factor ATF5-dependent UPRmt, which in turn promotes and exacerbates the intestinal senescence phenotype. By supplementation with the NAD+ precursor NMN, this intestinal senescence phenotype can be rescued to some extent, as evidenced by the recovery of intestinal organoid differentiation and the increased number of intestinal stem cells. 2. NAD+ depletion during intestinal senescence caused by mtDNA mutations There is impairment of NADH/NAD+ redox in Mut/Mut*** intestines, as manifested by the enriched NADH dehydrogenase complex assembly pathway. Through transfection of intestinal crypt cells with SoNar (a NADH/NAD+ sensor), a higher NADH/NAD+ ratio is observed in Mut/Mut*** mice, hinting the perturbed redox potential. Likewise, following transfection of intestinal crypt cells with FiNad (a NAD+ sensor), less NAD+ content is discovered in the Mut/Mut*** cells. All of these findings mirror NAD+ depletion in the intestinal senescence triggered by mtDNA mutations. Note: mtDNA mutations are classified into four types: negligible (WT/WT), low (WT/WT*), moderate (WT/Mut**) and high (Mut/Mut***). 3. The link between mtDNA mutation content and physiological intestinal senescence The small intestine of aged mouse intestine is characterized by decreased intestinal crypt number, increased villus length, higher expression of CDKN1A/p21 (a well-known senescence marker) and shorter telomere length, which is accompanied by accumulation of mtDNA mutations, primarily low-frequency (less than 0.05) point mutations. 4. LONP1 protein as a candidate marker for intestinal senescence caused by accumulated mtDNA mutations Mitochondrial unfolded protein response (UPRmt) is activated by a variety of mitochondrial stresses, including protein imbalances between mitochondria and the nucleus as well as impaired mitochondrial protein transport. The hallmarks of UPRmt are increased protein expression levels of LONP1, HSP60 and ClpP. Noteworthily, only LONP1 protein is specifically upregulated in senescent UPRmt activation triggered by accumulated mtDNA mutations, which may be a candidate biomarker for intestinal senescence. 5. The role of NAD+ in intestinal senescence induced by elevated mtDNA mutations. NAD+ repletion in vivo alleviates the small intestine senescent phenotypes caused by mtDNA mutation burden, and rescues the decreased colony formation efficiency in Mut/Mut*** intestinal organoids. NAD+-dependent UPRmt triggered by mtDNA mutations regulates intestinal senescence. These data further indicate that NAD+ depletion functions as a key mediator of the intestinal senescence induced by accumulated mtDNA mutations. 6. The role of NAD+ in the signal pathways regulating intestinal senescence caused by increased mtDNA mutations NAD+ repletion rescues the Foxl1 downregulation and Notch1 upregulation in Mut/Mut*** mice, suggesting that mtDNA mutation burden can regulate the function or number of niche cells through NAD+ depletion. In addition, NAD+ depletion caused by increased mtDNA mutation burden induces the decline of LGR5-positive intestinal cells via impairment of the Wnt/β-catenin pathway. 7. Conclusion NAD+ repletion is significant for the regulation of intestinal homeostasis, playing a critical role in rescuing the intestinal senescence phenotype caused by accumulated mtDNA mutations. Reference Yang, Liang et al. “NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations.” Nature communications vol. 15,1 546. 16 Jan. 2024, doi:10.1038/s41467-024-44808-z About BONTAC BONTAC is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. BONTAC has over 160 domestic and foreign patents, leading the industry of coenzyme and natural products. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NAD and NMN. High quality and stable supply of products can be ensured here. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC.
BONTAC in FHE 2024: Innovation of Raw Materials in Biosynthesis
Introduction On Feb 25-29, 2024, BONTAC was invited to 2024 Boao Healthy Food Science Conference & Exposition (FHE 2024) and made a discussion with the industry elites on the innovation of science and technology as well as the trend towards industry development in the health food area. Conference profile There are 15 academicians, 300 report experts, and over 2000 delegates from around the world gathering around the conference. More than 40 professional forums are planned in FHE 2024, attracting the active participation of domestic and foreign industry leaders such as Danone, Nestle and Pepsi. BONTAC star products in FHE 2024 By dirt of its innovative technology and strong R&D strength in the field of green biosynthesis, BONTAC stands out from the crowd. To date, there are over 170 global patents by BONTAC. BONTAC star products, including NMN, NADH and ginsenoside Rh2/Rg3, are present in FHE 2024, which are highly recognized by many brand owners. Many attendees are attracted to learn more and negotiate with BONTAC for further cooperation. Notably, Professor Chen Junshi from Chinese Academy of Engineering visited the booth of BONTAC, gave guidance to the team of BONTAC and highly praised the innovative achievements in the field of biosynthesis. Facilitating the development of high-quality health food via innovation of science and technology From the traditional healthcare with herbs to modern precision nutrition, health has always been the focus of people. With the progress of science and technology, the development of new functional nutrients has gradually relied on the support of technical innovation. In various niche areas of health, NMN has emerged as an essential force in health industry by leverage of its unique science base and broad application prospect. Mounting scientific research and clinical practice have attested the obvious efficacy of NMN in promoting the immunity, improving the cardiovascular health, and alleviating the fatigue. Conclusion FHE 2024 is the first domestic platform for the communication of scientific evidence on health beneficial food. In the future, BONTAC will continue to provide comprehensive solutions for anti-aging series products including coenzyme and natural extracts, and facilitate the development of high-quality food via innovation of science and technology. About BONTAC BONTAC has been dedicated to the green biosynthesis for 12 years, with the intention of creating a better life for human beings. Up till now, there are 173 patents by BONTAC. As the pioneer of NMN industry, BONTAC is the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Notably, BONTAC is the NMN raw material supplier of famous David Sinclair team at the Harvard University, who uses the raw materials of BONTAC in a paper titled “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging”.