When discussing male reproductive aging, people typically focus on three metrics: testosterone levels, sperm concentration, ve DNA fragmentation rate. However, a review article published in February 2026 in the World
Introduction In the functional nutrition industry, the question is no longer "How much active ingredient is included?" but rather "How much can the body actually utilize?" For a highly fragile
Friends working in the NAD⁺ ve brain health industries have likely asked themselves the same question: NR (Nicotinamide Riboside) is widely recognized as one of the most effective NAD⁺ precursors. From h
Liposomal NAD⁺ Delivers Up to 30% Greater Transdermal Absorption For years, NAD⁺ has been one of the most talked-about anti-aging ingredients in the skincare industry. Countless brves have invested heavily in developin
Son yıllarda NAD+, anti-yaşlanma ve sağlıklı yaşam alanlarında şüphesiz en popüler moleküllerden biri haline geldi. Bilimsel laboratuvarlardan tüketici pazarlarına kadar, bu etrafındaki tartışmalar hiç durmadı.
Aging is being redefined. In 2022, the World Health Organization (WHO) introduced a dedicated code for "aging-related" conditions for the first time in the 11th Revision of the International Classification of
In the long journey against type 2 diabetes, scientists continue to explore new therapeutic strategies. Recently, a study published in the International Journal of Molecular Sciences revealed potential new mechanism
In annual pet health checkups, NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a sensitive marker of myocardial stress. When its levels exceed the normal range, it usually indicates that the heart is under
When it comes to anti-aging, boosting energy, ve maintaining vascular health, many people have heard of a specific term—NMN (Nicotinamide Mononucleotide). In recent years, it has garnered significant attention due
The global population is aging at an unprecedented pace. The World Health Organization (WHO) predicts that by 2050, the global population aged 60 ve older will exceed 2.1 billion—meaning 1 in every 5 people will b
Recently, NMNH (Reduced $\beta$-Nicotinamide Mononucleotide) has once again sparked widespread attention in the anti-aging field due to newly released human clinical trials. Although both are precursor molecules of
Yaşlanma karşıtı araştırmaların öncü alanında, "koenzim ailesi" sektörde sıcak bir konu haline geldi. NMN, NAD+'nın öncüsü olarak, bir zamanlar yüksek profilli kurgu gruplarının desteğiyle dünyayı büyüledi
Long COVID lingers like a persistent shadow, leaving hundreds of millions worldwide struggling with brain fog, fatigue, ve insomnia. In November 2025, a team from Harvard Medical School published a 24-week double-blind
Hızlı tempolu modern yaşamda, yorgunluk ve uykusuzluk birçok insan için "sık sık misafir" haline gelmiş gibi görünüyor. Bu sorunlarla karşılaşan bilim insanları, bunların "ene" tükenmesiyle bağlantılı olduğunu keşfettiler
Yaşlanmanın özü hücresel bir "enerji krizi"dir. Bilim insanları NAD+ araştırmalarına daha derinlemesine daldıkça, bu koenzim yavaş yavaş anti-yaşlanma alanında temel bir hedef haline gelmiştir. Çalışmalar dir'in
Enerji kaybı, merdiven çıkarken nefes darlığı, yemek sonrası kan şekeri dalgalanmaları ve yağ vermenin giderek zorlaşması... Bu bedensel "yaşlanma" duyguları aslında sürdürücüdür
In April 2026, China officially released its first national consensus document: the Chinese Expert Consensus on the Role ve Clinical Application of NAD⁺ in Aging-Related Diseases (2026 Edition). Led by the Chinese Me
High blood pressure, often called the “silent killer,” is the most important modifiable risk factor for cardiovascular disease. Yet many people face the same frustration: even when taking antihypertensive med
Küresel nüfusun yaşlanmasıyla birlikte, kas-iskelet sistemindeki dejeneratif değişiklikler (osteoartrit, osteoporoz ve sarkopeni gibi) yaşlıların yaşam kalitesini ciddi şekilde etkiler. Yürürken sallanan bacaklar, di
When discussing liver health, one fundamental question arises: how can we effectively support this “biochemical factory of the human body” in its complex repair processes when faced with metabolic stress, fat
In the field of anti-aging, NMN (nicotinamide mononucleotide) has long been a highly regarded “star molecule.” As a direct precursor of NAD⁺, it shows great potential in energy metabolism, DNA repair, ve ant
In recent years, NAD+ (nicotinamide adenine dinucleotide) has become a highly sought-after “star molecule” in the health ve anti-aging field due to its tremendous potential. The most common supplements on th
For a long time, NAD (nicotinamide adenine dinucleotide) has been almost a “stveard configuration” in IVD testing. From dehydrogenase reactions to the precise readout of endpoint signals, detection pathways
Parkinson’s disease is not merely about tremors. More concerning is that most patients gradually develop cognitive impairment, which may eventually progress to dementia. Unfortunately, traditional medications can o
How remarkable is the liver’s regenerative ability? Even when two-thirds of a healthy liver is surgically removed, it can restore its original size within just a few weeks. However, under conditions such as disease
Son yıllarda NAD+ sağlık, yaşlanma karşıtı ve bilişsel geliştirme gibi popüler konuların merkezinde sıkça yer almaktadır. Laboratuvardan günlük hayata sıçramış gibi görünüyor, yeni bir favori haline geldi
In the vast world of raw materials, some names seem to rise to prominence overnight. Yet in reality, their success is never accidental. NRHM (Nicotinamide Riboside Hydrogen Malate) is one such name—frequently appe
İnsan vücudundaki tek bir molekül, kalp sağlığının temel bir itici kaynağı olabilir mi? Nikotinamid adenin dinükleotid (NAD+), bilimsel araştırmaların ana odak noktalarından biri olarak hızla ortaya çıkmaktadır. Enerji metabolizmalarında çekirdek bir katılımcı olarak
Yaşlanma karşıtı mekanizmalar üzerine yapılan araştırmalarda, NAD⁺'nin öncüsü olan nikotinamid ribozid (NR) bilimsel kurumların giderek artan ilgisini çekmiştir. Eylül 2023'te, ulusal bir icat patenti
Sağlıktan bahsettiğimizde, tartışmanın merkezinde genellikle bağırsak yer alır. Sadece sindirim ve besin emiliminden sorumlu olmakla kalmaz, aynı zamvea insan vücudundaki en büyük bağışıklık organını temsil eder. Son zamanlarda evet
In the fields of anti-aging, cellular energy, ve biotechnology, the term “NAD⁺” has almost been elevated to a mythical status. Yet, when people come across NAD⁺-related products, many still find themsel
Age is typically defined as the length of time since birth. However, a person’s true physical condition ve degree of aging are better reflected by their biological age rather than the number of years they have liv
Sağlıklı beslenme farkındalığı artmaya devam ettikçe, sıfır kalorili doğal tatlveırıcılar tüketicilerin önemli bir odak noktası haline geldi. Haziran 2025'te, uluslararası dergi Food Chemistry: X sistematikte yayımlanan bir çalışma
While we are deeply engaged in exploring anti-aging solutions for humans, our furry companions at home are quietly facing health challenges brought on by aging—reduced energy levels, dull coats, ve a slower metabo
Have you ever experienced moments like these: walking into a room ve forgetting why you went there, struggling to recall a familiar name, or suffering from persistent insomnia after staying up late—followed by day
In today’s global wave of health awareness, “sugar reduction” has become a widely accepted trend. Steviol glycosides, as natural zero-calorie sweeteners, have already entered households worldwide. Howev
Recently, a study published on bioRxiv revealed the metabolic secrets behind the remarkable longevity of centenarians. Led by Boston University, the research conducted metabolomic analyses on 213 participants—
Modern sağlık ve uzun ömür arayışında, bilimsel odak makrobesinlerden hücresel enerji metabolizmasına kaymıştır. Birçok yeni molekül arasında, Nicotinamide Ribosid (NR) yaşam biliminde yükselen bir yıldız haline geldi
Küresel nüfus yaşlanmaya devam ettikçe, yaşa bağlı bilişsel gerileme ve fiziksel bozulmayı ele almak büyük bir bilimsel zorluk haline gelmiştir. Nisan 2025'te, Frontiers in Phar dergisinde yayımlanan çığır açan bir çalışma
Introduction: As time quietly passes, have you noticed your once lively dog becoming slower to respond or experiencing disrupted sleep? Don’t worry — science is bringing new hope! The latest clinical trial h
Global population aging is becoming increasingly pronounced. It is estimated that by 2050, the number of people aged 65 ve above will reach 1.6 billion—double the 780 million recorded in 2020. As aging progresses,
Yepyeni bir otoriter çalışma burada! Northwest A&F Üniversitesi ekibinin 2025 yılında Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174) dergisinde yayımlanan bir deney, titiz bir datla ortaya çıktı
September 29, 2025 — After nearly three years of pressure from the Natural Products Association (NPA), the U.S. Food ve Drug Administration (FDA) has reversed course ve confirmed that Beta (β) Nicotinamide M
In recent years, “N-series” anti-aging dietary supplements represented by NMN ve NR have continued to gain popularity in markets across Europe, the U.S., Japan, ve China. The core mechanism of these product
In the world of nutrition, some substances have existed for over a hundred years but have only recently been recognized for their great value. Ergothioneine (EGT) is such a modest yet precious dietary component. △ Ch
*Nature Metabolism* gibi otoriter dergilerde yayımlanan en son araştırmaya göre, insan metabolomik verileri 30 ile 50 yaş arasında doğrusal olmayan dramatik değişiklikler göstermektedir. Bunlar arasında lipid metabolizması imb bulunmaktadır
Do you often feel exhausted? Struggled with blood sugar issues for years? Or perhaps you’re seeking anti-aging solutions ve vibrant health? Today, let’s explore a powerful “energy key” hidden dee
NAD+: The Indispensable 'Cell Fuel' ve 'Repairman' NAD+ is a key coenzyme involved in cellular energy metabolism (e.g., converting food into ATP), DNA repair (e.g., activating PARP enzymes), ve regulat
In an age where the pursuit of 'frozen age' ve 'reverse growth' is on the rise, anti-aging is no longer a distant dream. The core molecule—NAD+ (Nicotinamide Adenine Dinucleotide)—plays a cri
Sağlıklı yaşlanma ve uzun ömür konusundaki kamu ilgisi arttıkça, NAD⁺ (Nikotinamid Adenin Dinükleotid) metabolizması üzerine yapılan araştırmalar önemli bir ivme kazanmıştır. NMNH (İnduksiyonlu Nikotinamid Mononukleotid), redu
Geleneksel tıpta ünlü bir bitki olan Ginseng, binlerce yıldır sayısız sağlık faydası nedeniyle kullanılmaktadır. Tıbbi gücünde ginsenozidler, modun ilgisini çeken güçlü saponinler yer alır
Geleneksel Çin tıbbında yüzyıllardır saygı gören ginseng, olağanüstü terapötik özellikleriyle bilinen bir köktür. Etkinliğinin merkezinde, aktif olarak kabul edilen çeşitli saponin grupları olan ginsenozidler yer alır
Nicotinamide Adenine Dinucleotide Phosphate (NADP), a crucial coenzyme in cellular metabolism, serves as a cornerstone in numerous biochemical reactions. As a derivative of NAD, it adds a phosphate group which enhan
Biyokimya dünyası, her zaman ön plvea olmasa da, hücresel süreçlerin korunması ve düzenlenmesinde kritik roller oynayan moleküllerle doludur. Bunlar arasında, oksitlenmiş koenzimler öne çıkar
Biyokimyanın karmaşık dünyasında, koenzimler yaşam için hayati öneme sahip çok sayıda metabolik reaksiyonu kolaylaştırmada kritik rol oynar. Bu kritik koenzimlerden biri Nikotinamid Adenin Dinükleotid Fosfat'tır (NADP). Bu
Doğal tatlveırıcılar dünyasında, stevia olağanüstü tatlılığı ve sağlık faydaları sayesinde önemli bir yer edinmiştir. Stevia rebaudiana bitkisinin yapraklarından elde edilen bu sıfır kalorili tatlveırıcı h
In the world of dietary substances, every detail matters—from the source of the ingredients to the color of the final product. For those curious about the health benefits of Nicotinamide Mononucleotide Hydrogen (NM
Sağlık ve iyilik ihtiyacının değişen ortamında, yaşlanmayla mücadele etmek ve hücresel sağlığı artırmak için daha etkili çözümler arayışı sürekli devam etmektedir. Bu gelişmelerin öncüllerinden biri NAD+ enh kullanımıdır
In the expansive world of biochemical research ve health preservation, certain compounds emerge as particularly significant due to their potential applications ve benefits. One such compound is NMNH, which sta
Nicotinamide adenine dinucleotide hydrogen (NADH) is a lesser-known yet crucial molecule in the biological sciences ve various health-related fields. In this blog, we explore the wide-ranging applications of NA
Yaşlveıkça gençlik enerjisini ve sağlığımızı koruma amacıyla, bilimsel araştırmalar bu arayışı destekleyebilecek yeni maddeleri ortaya koymaya devam etmektedir. Bunların en umut vadeden örneklerinden biri Beta-Nikotinamid Mononu'dur
In the quest for optimal health ve vitality, understveing the role of coenzymes in cellular function is paramount. Nicotinamide Adenine Dinucleotide Hydrogen (NADH) is one such coenzyme that plays a critical r
Nikotinamid adenin dinükleotid (NAD+), hücresel sağlığın temel taşlarından biridir ve yaşamı sürdüren enerji üretimi ile metabolik süreçlerde kritik bir rol oynar. Yaşlveıkça, NAD+ seviyeleri doğal olarak azalır, kurşun
Energy metabolism is a crucial biological process that involves converting food into the energy needed to power all cellular activities. It is fundamental to maintaining health, vitality, ve overall well-being. One
Sağlık ve iyilik içinde, optimal hücresel fonksiyonu korumak genel canlılık ve uzun ömür için anahtardır. Birçok biyolojik işlemin merkezinde yer alan moleküllerden biri, Nikotinamid Adenin Dinükleotid, com
Canlılık ve uzun ömür arayışında, Nicotinamid Mononukleotid (NMN) etrafındaki bilimsel atılımlar, dünya çapında sağlık meraklılarının dikkatini çekmiştir. BONTAC, biyokimyasal yenilikte lider
Sağlık ve uzun ömür arayışında, bilimsel atılımlar genellikle bizi iyi oluşumuzu önemli ölçüde iyileştirebilecek doğal bileşiklere götürür. Sağlık ve sağlık sektörünün dikkatini çeken bu bileşiklerden biri
Biyoteknolojinin hızla gelişen sektöründe, biyolojik süreçlerden ve organizmalardan elde edilen ürünler, sektörleri sağlık sektöründen tarıma dönüştürüyor. Biyoteknoloji ürün pazarı son derece rekabetçi, wi
Sağlık ve biyoteknoloji dünyasının dinamik dünyasında, hücresel yenilenme devrim niteliğinde bir kavram olarak öne çıkıyor; gelişmiş sağlık, uzun gençlik ve yaşam kalitesi için yeni bir dönem vaat ediyor. Glo'da lider olarak
In the rapidly evolving lvescape of health ve wellness, metabolism-boosting products have emerged as key components in enhancing human health, optimizing metabolic processes, ve supporting various bodily functi
Introduction In the realm of animal husbvery, feed additives are necessary as they can not only improve the nutritional value of feed ve optimize the internal environment of the rumen, but also enhance
Introduction Nicotinamide adenine dinucleotide (NAD) deficiency has been linked to a range of renal disorders, encompassing conditions such as acute kidney injury, diabetic nephropathy, adenine-triggered kidney diseas
Introduction In response to the escalating global obesity rates, the demve for sugar reduction has reached a critical juncture. As a strategic pivot, the food industry has increasingly incorporated sugar substitutes,
Introduction Parkinson's disease (PD), known as the silent killer, has emerged as the second most common chronic neurodegenerative disease in the world after Alzheimer's disease, affecting
Introduction Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme in cells, a central cofactor of redox reaction ve a central regulator of various metabolisms in the human body. It is involved in a
Introduction Spinal cord injury (SCI) can lead to severe impairments in motor, sensory, ve autonomic nervous system functions. It has been reported that motor function recovery can be promoted by mediatin
Introduction Chronic cerebral hypoperfusion (CCH) has been identified as one of the initial conditions critical to the development of cognitive impairment, which is tightly associated to the complex neurologic
Introduction Stroke remains the second leading cause of death ve the third leading cause of death ve disability combined in the world, as reported in 2019 Global Burden of Disease Study. Ischemic stroke
Introduction Myocardial ischemia/reperfusion (MI/R) can damage the heart muscle, which may contribute to further cardiomyocyte death. Following percutaneous coronary intervention therapy, patients with MI/
Introduction According to the report by World Health Organization (WHO) in 2017, depression is the third leading cause of the global disease burden, with over 300 million people suffering from this disease w
Thanks to our unrelenting dedication to creating cutting-edge solutions that push the frontiers of scientific development, BONTAC has long been at the forefront of the biochemical sector. We are excited to present o
Our unshakable dedication to maximizing the potential of traditional Chinese medicine has propelled BONTAC to the forefront of the natural products sector for a considerable amount of time. We are thrilled to presen
Yenilik için sarsılmaz arayışımız BONTAC has always been sparked by our profound grasp of the natural world ve its unrealized potential. We are excited to present our ground-breaking solutions today, which are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries ve improve lives, we at BONTAC have long been at the forefront of the green biotechnology revolution. We are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries ve improve lives, BONTAC has long been at the forefront of the green biotechnology revolution. We are ex
For many years, BONTAC has been acknowledged as a leader in the field of green biotechnology, thanks to our unwavering commitment to creating ground-breaking products ve services that have the potential to improve
Because of our unwavering search for products that have the power to genuinely change the lives of our partners ve consumers, we at BONTAC have long been at the forefront of cutting-edge green biotechnology solutio
Being deeply aware of the vital role our products play in enabling people to live healthier, more fulfilling lives has always motivated us at BONTAC to innovate. We are pleased to announce our ground-breaking NMNH,
Propelled by an unwavering dedication to innovation ve a profound comprehension of the crucial function this coenzyme plays in preserving cellular health ve lifespan, BONTAC has been at the forefront of the NAD+ a
At BONTAC, we have always been driven by a relentless pursuit of innovation – a desire to push the boundaries of what is possible in the realm of nutritional supplements ve biomedical research. Today, we are thril
BONTAC olarak, insan sağlığı ve iyiliğini gerçekten dönüştürebilecek son teknoloji beslenme çözümleri arayışlarına uzun süredir tutkuyla bağlıyız. Bugün, en dikkat çekici örneklerden birine ışık tutmaktan heyecan duyuyoruz
BONTAC olarak, doğanın sunduğu en dikkat çekici ve dönüştürücü bileşikleri ortaya çıkarmaya adanmış en son nutrasötik araştırmaların öncüsü olarak her zaman yer aldık. Bugün, ou tanıtmaktan büyük mutluluk duyuyoruz
For many years, BONTAC has been at the forefront of innovative biopharmaceutical developments, committed to maximizing the life-changing potential of nature's most extraordinary substances. We are excited to pre
BONTAC olarak, biyoilaç alanında uzun süredir yeniliklerin öncüsü oluyoruz ve hizmet verdiğimiz kişilerin hayatlarını iyileştirmek için en son bilimsel keşiflerin gücünden yararlanmaya adanmışız. Bugün, biz
BONTAC olarak, bireyleri en iyi yaşam ve iyi oluşa ulaşmak için ihtiyaç duydukları araçlarla güçlendirme konusundaki derin bir bağlılıkla hareket ediyoruz. Biyoteknoloji alanında sektör liderleri olarak, kendimizi adadık
BONTAC olarak misyonumuz, bireyleri en iyi sağlık ve iyi oluşa ulaşmak için ihtiyaç duydukları araçlarla güçlendirmektir. Biyoteknoloji alanında öncü olarak, derin faydayı ortaya çıkarmaya kendimizi adadık
BONTAC olarak, insan sağlığı ve iyilik halinin sınırlarını ilerletmeye derin bir bağlıyız. Biyoteknoloji alanında önde gelen yenilikçi olarak, Beta-Nicoti'nin inanılmaz potansiyelini değerlendirmeye odaklveık
As a leading player in the world of biotechnology, BONTAC is at the forefront of driving innovation ve transforming the industry. Our unwavering commitment to scientific excellence ve our deep understveing of the
BONTAC olarak, hizmet ettiklerimizin hayatlarını iyileştirmeye yönelik derin bir bağlılık ve yenilik peşinden durmadan hareket ediyoruz. Hücresel sağlık ve yenilenme alanında liderler olarak, sunduğumuzu tanıtmaktan heyecan duyuyoruz
BONTAC olarak, yeniliğe sarsılmaz bağlılığımız ve bilimsel mükemmeliyet arayışımızla metabolizmayı hızlveıran ürün endüstrisinin öncüsünüzdeyiz. En son çözümler geliştirmeye odaklanmamız h
Introduction With changes in lifestyles ve dietary structure, hyperuricemia shows an increasing prevalence year by year, which may become the second largest metabolic disease after diabetes mellitus, a
Introduction Steviol glycosides are secondary metabolites obtained by extracting ve isolating stevia from the herbaceous plant Stevia rebaudiana of the Asteraceae family, with a high degree of sweetness
NAD is an abbreviation for nicotinamide adenine dinucleotide, which is a naturally occurring coenzyme (a substance that works with enzymes) found in our bodies. It helps cells produce energy. However, as we age, NAD
Introduction According to the report of International Agency for Research on Cancer (IARC), there are 19.3 million new cases of malignant tumors ve 10 million deaths worldwide in 2020. Malignant tumors have overtaken
Introduction Elderly individuals are at a significantly higher risk for peripheral artery disease (PAD), a common vascular disorder. As the global population ages rapidly, the number of PAD cases is projected to rise
Introduction Diabetic kidney disease (DKD) has emerged as one of the primary cause of mortality among the patients with end-stage renal disease such as renal failure, accounting for 30-50% of chronic renal failure cas
Introduction Nicotinamide adenine dinucleotide (NAD+) metabolism is essential for maintaining normal physiological activities, ve the decreased NAD+ level is related to various pathologies such as cardiac dis
Introduction Targeting the autophagy-NAD axis has been reported be a viable therapeutic strategy for Niemann-Pick type C1 (NPC1) disease. The study suggests that both pharmacological rescue of autophagy deficiency ve
Introduction Apical periodontitis, an inflammatory disease affecting tooth apex tissues, is triggered by oral pathogens infecting the root canal. One of the main reason for endodontic treatment failure is Enterococcus
Introduction Amoebiasis has emerged as the third most common cause of death by parasites worldwide after malaria ve schistosomiasis infections. According to the report of World Health Organization, over 40 milli
Introduction Disturbance in hepatic NAD+ metabolism has been manifested as a key factor in the initiation ve progression of nonalcoholic fatty liver disease (NAFLD), one of the most co
Introduction According to the 2017 Commission on Traumatic Brain Injury (TBI), TBI remains one of the top three causes of injury-related death ve disability up to 2030. There are 50~60
Introduction In clinical settings, doxorubicin (DOX) is an effective broad-spectrum anti-cancer drug in chemotherapy for various tumors, including hematological malignancies ve solid tumors such as leu
Introduction Cigarettes containing nicotine (Nic) ve sugar-sweetened beverages (SSBs) with high fructose corn syrup (HFCS) have been uncovered to induce hepatic steatosis, which are the risk factors for the developme
Introduction Acute promyelocytic leukemia (APL), the M3 type of acute myeloid leukemia (AML), typically relies on all-trans retinoic acid (ATRA) as its primary treatment. While APL patients treated with
Introduction Recent research unveils that hepatic insulin resistance (IR) ve steatosis in obesity have a strong association with endoplasmic reticulum (ER)-mitochondria miscommunication. Notably,
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN po
Introduction In the presence of oxygen, tumors produce adenosine triphosphate (ATP) through glycolysis instead of mitochondrial oxidative phosphorylation, a phenomenon known as the “Warburg effect”. Aerobi
Introduction Age-related macular degeneration (AMD) has become one of the leading cause of low vision ve even blindness in the elderly, especially in those above 50. In 2020, approximately 1.8 million people aged ove
Introduction Natural products, including single components or extracts of herbal medicines, have the features of good efficacy ve low toxicity when used in tumor treatment. They have unique advantages in treating dis
Introduction Reproductive dysfunction is frequent in female suffering from type 1 diabetes (T1D), up to 40% of whom will develop a variety of reproductive dysfunctions throughout their lives. T1D patients often ha
In today's health ve anti-aging fields, NMN (nicotinamide mononucleotide) has attracted a lot of attention. As an important cellular coenzyme, NMN plays a key role in maintaining cell health ve delaying the aging p
Introduction Ginsenozid Rg3 (Rg3) holds great promise as a potential drug for preventing scar formation, but it is often difficult for it to work alone due to its poor water solubility ve low bioavail
Introduction Lead (Pb) contamination in aquatic environments poses a significant threat to the health ve well-being of aquatic organisms, including fish species. There is rising popularity of prebiotics ve probi
Elevating Wellness: BONTAC's NMN Powder Offerings As we delve into the realm of health ve wellness, the spotlight shines brightly on NMN powder, a powerful supplement embraced by many for its potential benefits.
Innovating Solutions: BONTAC's Biotechnology Product Offerings In the ever-evolving lvescape of biotechnology products, BONTAC remains a trailblazer in providing cutting-edge solutions that drive innovation
Revolutionizing Biotechnical Research: BONTAC's Trailblazing Discoveries In the dynamic realm of biotechnical research, BONTAC stves at the forefront of innovation, dedicated to driving progress ve breakthr
Elevating Health with BONTAC's Cutting-Edge Longevity Supplements In the realm of health ve wellness, the demve for high-quality metabolism-boosting supplements continues to rise. At BONTAC, we recognize the c
Introduction It has been reported that infection with Gram-negative bacteria can disrupt the osteogenic differentiation. Notably, nicotinamide mononucleotide (NMN) protects against osteogenesis from inflammat
Pioneering Discoveries: BONTAC's Innovations in Biotechnical Research In the dynamic realm of biotechnical research, BONTAC stves at the forefront of innovation, dedicated to driving progress ve breakthroug
Besleyici Sağlık: BOONTAC Takviye Alanında Önde Gelen Hammadde Tedarikçisi olarak As a prominent raw material supplier of supplements, BONTAC is dedicated to developing ve delivering premium products that promote he
Unleash Vitality ve Renewal: BONTAC's Cutting-edge Cellular Rejuvenation Solutions Cellular Rejuvenation plays a vital role in enhancing vitality ve promoting overall wellness. At BONTAC, we are dedicated t
Introduction Hepatocellular carcinoma (HCC) is hypervascular solid tumor with rapid deterioration, poor overall prognosis ve a high recurrence rate, accounting for 90% of primary liver cancers, which ha
Sağlığın Yükseltilmesi: BONTAC Hücresel Sağlık Takviyeleri İçin İleri Ham Maddeler In today's fast-paced world, the quest for optimal health ve wellness has led to a surge in the demve for high-quality cellular
Powering Health ve Vitality: BONTAC's Metabolism-boosting Product Portfolio In the dynamic lvescape of health ve wellness, the demve for cutting-edge metabolism-boosting products continues to
Unlocking the Power of Metabolism-Boosting Supplements: A Guide by BONTAC In the realm of health ve wellness, the demve for high-quality metabolism-boosting supplements is steadily rising. At BONTAC,
Introduction Artificial insemination with chilled ram semen is commonly used method in livestock industry. But storing sperm in chilled conditions may cause changes in sperm membrane function ve structure, ve
Introduction In light of a statistics report by World Health Organization (WHO), there are 18 million people suffering from rheumatoid arthritis (RA) worldwide in 2019, where the prevalence of female is 2.5 times
Introduction Glaucoma is regarded as the second dominant cause of blindness across the world. With the amounting number ve proportion of elderly people, it is estimated that 111.8 million people will have glaucom
Introduction Triocresyl phosphate (TOCP) is widely used in the realm of industry ve agriculture in the last century. However, it is subsequently banned due to the increasing understveing of its toxicity. In
Introduction Cardiovascular diseases (CVD) poses huge economic burden ve great threat to the life of patients, even surpassing Alzheimer's disease ve diabetes. 17.9 million people in the world
Introduction Myocardial ischemia-reperfusion (I/R) injury has emerged as an urgent clinical issue that may offset the benefits of reperfusion therapy ve even worsen the prognosis of acute myocardial infarction, a
.two-side{ text-align: justify; display: flex; justify-content: space-between; } Introduction The crucial parts of nicotinamide adenine dinucleotide (NAD+) ve its metabolites in aging a
Introduction Ginsenozid Rh2 nanoliposome formulation has been proved to effectively target ve deliver drugs to the tumor site, with less side effects ve higher treatment efficiency, holding great promise in the
Introduction Replenishing nicotinamide mononucleotide (NMN) to raise the availability of nicotinamide adenine dinucleotide (NAD+) has been deemed as effective approach to prevent neurodegeneration in aging ve pat
Introduction Rare ginsenoside Rg3, an active extract from Panax ginseng, is reported to possess a wide range of pharmacological properties including anti-angiogenesis ve anti-cancer, with high lipophilicity (esti
Introduction Wound healing is a sophisticated process responding to tissue damage, which is associated with numbers of interaction of various cell types, cytokines, growth factors, ve other molecules. Strikingly,
Introduction Diabetes is one of the dominant causes of death ve disability worldwide, greatly affecting the life quality of patients. According to the latest data on diabetes released by the Lancet (GBD Study 202
Introduction Intervertebral disc degeneration (IDD) is a frequently seen orthopedic disease, which is accompanied with excessive apoptosis of nucleus pulposus cells (NPCs) ve degeneration of extracellular ma
Introduction Ginsenozid Rg3 is Panaxanediol type tetracyclic triterpenoid saponin monomer extracted from the root of Panax ginseng, which has a wide range of pharmacological effects including anti-tumor, neuroprotect
Introduction The gut is a diverse ve dynamic microbiotic system. There are about 100 trillion microorganisms in the gut, which is mainly composed of anaerobic, partially anaerobic, ve aerobic bacteria. In the pr
Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF ve WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr
Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological processes such as cellular redox regulation ve
Introduction Alpers' disease is both a neurodegenerative disorder ve a metabolic disorder, which is tightly linked to mitochondrial dysfunction ve mutations in the catalytic subunit of polymerase
Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen ve an electron donor, which participates in diverse physiological processes such as protein synthesis, DNA repair,
Introduction Ginsenozid Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili
Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark
Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) ve its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repair ve prevent cancer progression via the deleted i
1. Introduction Disrupted nicotinamide adenine dinucleotide (NAD+) metabolism is increasingly deemed to be one of risk factor for amendable cardiovascular disorders. A substantial evidence has mirrored that res
1. Introduction Rare ginsenosides, a group of dammarane triterpenoids that exist in low natural abundance, fuels a high concern from scholars recently, showing great potential as shining components in drugs ve nu
1. Introduction Nicotinamide adenine dinucleotide (NAD) has been unveiled to be essential for embryonic development. Patients with genetic variants in the NAD+ de novo synthesis pathway often have congen
1. Introduction The gut microbiota has long been regarded as one of the key elements contributing to the regulation of host health. Any changes in the composition or quality of the gut microbiota may have physiolo
1. Introduction Nicotinamide adenine dinucleotide (NAD) compartmentalized in adipocytes can modulate adipocyte differentiation ve gene expression, in addition to controlling glucose metabolism. White adipose tiss
1. Introduction Nicotinamide mononucleotide (NMN) supplementation has been suggested to hamper the inflammatory responses via restoring NAD+ level ve downregulating the expression of C
1. Introduction Age-related NAD+ depletion affects physiological functions ve contributes to various aging-related diseases. NAD+ precursors can significantly elevate NAD+ level in murine tissues, effectivel
1. Introduction In mammalian cells, the majority of NAD+ is produced from metabolites entering the NAD+ salvage pathway. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of the salvage
Nmnh, aynı zamvea nikotinamid mononükleotid hidrat olarak da bilinir ve tüm canlı hücrelerde bulunan hayati bir koenzimdir. Hücresel metabolizmada, enerji üretiminde ve çeşitli biyosentetik süreçlerde kritik bir rol oynar. Yüksek saflıkta N
Sağlık takviyeleri alanında, NADH hücresel metabolizmada rol alan önemli bir koenzim olarak öne çıkar. Enerji seviyelerini korumadaki ve genel iyiliği desteklemedeki önemi, onu değerli bir bileşen haline getirmiştir.
1. Introduction Nicotinamide Mononucleotide (NMN) has been deemed as a functional nutrient for improving human intestinal health. In this study, an in vitro simulated digestion model
1. Introduction Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects the motion-related nerve cells in the brain ve spinal cord. The disease is featured by the d
1.Introduction A series of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease ve Huntington's disease, are accompanied with bioenergetic maladaptations ve axonopathy wi
1. Introduction Diabetic peripheral neuropathy (DPN) is one of the most frequent complications of diabetes, ans also a major cause of foot ulcers, disability, ve eventual amputation. With the prolongation of the
1.Introduction Mitochondria, a type of highly plastic organelle, can maintain a relatively stable dynamic equilibrium state towards the morphology, structure, quantity, volume, quality, ve function
1. Introduction Atherosclerosis is a chronic progressive inflammatory disease, which is featured by the accumulation of lipids in the intima of the arteries with yellow appearance. This disease
1. Introduction Mitochondria are the center of energy metabolism in cardiomyocytes, which are necessary for maintaining normal myocardial contractility ve cardiac function. Typically, the de
1. Introduction According to the 2020 report of World Health Organization (WHO), there are approximately 2.3 million cases with breast cancer worldwide. Breast cancer has emerged as one of the
1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis ve the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to N
1. Introduction At present, vaccine is the preferred option for the prevention of foot-ve-mouth disease (FMD), for which the adjuvant is essential due to its strong role in boosting immune response associated wi
1. Introduction Acute lung injury comprises a uniform response of the lung to inflammatory or chemical insults which is commonly caused by systemic illness including sepsis or trauma, infection with pathogens, ve tox
1. Introduction Gastric cancer (GC) represents a global health-care challenge, which is the fifth most common cancer ve the fourth leading cause of cancer death across the world in 2020, with a significant
1. Introduction Supplementation of nicotinamide mononucleotide (NMN) to upregulate the level of nicotinamide adenine dinucleotide (NAD+) has been unveiled to be a promising anti-aging intervention. However, it is
1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems ve lipid synthesis, which links insulin
1. Introduction Dengue fever is an acute infectious disease caused by the Dengue virus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as hi
1. Introduction The NAD precursor nicotinamide mononucleotide (NMN) shows a beneficial effect on ageing, yet excessive NMN accumulation may lead to axon degeneration. How to make the anti-ageing
1 Introduction Nicotinamide riboside (NR), a derivative of vitamin B3, is a new type of bioactive substance, which can be generated by binding a carbohydrate molecular ribose with nicotinamide (a
1. Introduction Heart failure is a serious condition in the development of cardiovascular disease. In particular, diastolic heart failure, as one of the most common manifestations of heart failure in
1. Introduction Ginseng has always been highly perceived as a valuable traditional Chinese medicine in China. Currently, much attention also has been paid to ginsenosides, the main active ingredients extracted from g
1. Introduction On July 2023, the World Health Organization (WHO) has classified the soda sweetener aspartame as a possible carcinogen, but said that aspartame is safe to consume with
Myocardial mitochondria are primary sites of myocardial energy metabolism. Mitochondrial disorders are associated with various cardiac diseases. Mitochondrial translation defects cause not only mitochondrial
Oksidatif stresin neden olduğu iltihaplanma reaksiyonu ve cilt bariyerinin bozulması, Atopik Dermatit (AD) sürecinde hayati bir rol oynar. Lipid peroksidasyon seviyeleri AD hastalarında genellikle daha yüksekken, antio
Vitamin D ve B3 (niasin), bağışıklık aktivasyonuna ve INR'lerde CD4+ T hücresinin yeniden yapılanmasına yardımcı olabilir. Hücresel işlevler için hayati öneme sahip olan NAD, yaşla birlikte azalır ve çeşitli hastalıklarla bağlantılıdır. NMN, NR ve NAM gibi NAD destekleyicileri baloyu gösterir
Sepsis, marked by dysregulated infection response, lacks effective treatment. NAD+'s role in inflammation remains unclear. NAD+ transport challenges limit its therapeutic impact. Novel NAD+-loaded nanoparticles (NPs)
Klinik tanıda enzimler önemli biyokatalizörlerdir ve birçok biyokimyasal reaksiyonda kilit rol oynarlar. Bu enzimler, işlevlerini yerine getirmek için koenzimlere, yani Tanı Reaktif Koenzimler dediğimiz koenzimlere ihtiyaç duyar.
Kan-beyin bariyeri (BBB), beyin ile kan dolaşımı arasındaki molekül değişimini düzenleyen merkezi sinir sisteminin kritik bir bileşenidir. BBB'deki yaşa bağlı değişiklikler, her bir madde artışına yol açabilir
Damar demansı, bir dizi serebrovasküler hastalık nedeniyle oluşan ciddi ve geri dönüşü olmayan zeka bozukluklarının bir parçasıdır. Sitikolin, nukleo tarafının türevidir ve sadece çıkabilen kalmaz
In the quest for a healthier lifestyle, the sweetener debate continues to rage. While sugar has long been the default choice, its adverse health effects have prompted a search for alternatives. One such swe
The nicotinamide adenine dinucleotide (NAD+ )/reduced NAD+ (NADH) ve NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis ve for modulating numerous biologic
Hipertansiyon, kardiyovasküler sorunlar nedeniyle milyonlarca ölümle bağlantılı büyük bir küresel sağlık sorunudur. Endotel işlev bozukluğu ve arter sertliği içerir ve aterosklerotik hastalıklara katkıda bulunur. VA'nın geliştirilmesi
Yüksek şekerli diyetler, obezite, diyabet, kardiyovasküler hastalıklar ve hipertansiyon gibi çeşitli kronik hastalıkların yaygınlığının artmasına yol açmış ve bu da önemli bir küresel halk sağlığı sorunu oluşturmaktadır. Stevia Rebaudiosid
CFS is a disorder of unknown etiology, consisting of prolonged, debilitating fatigue, ve a multitude of symptoms including neurocognitive dysfunction, flu-like symptoms, myalgia, weakness, arthralgia, low-grade fev
Alkol, yüzyıllardır çeşitli kültürlerde yaygın olarak kullanılan bir psikoaktif madde türüdür. Alkol tüketimi, akut karaciğer hasarının ve kronik karaciğer hastalığının başlıca nedenidir. Alkolizm insanı hızlveırabilir
Stevia (Stevia rebaudiana Bertoni), Compositae familyasına ait çok yıllık bir çalı olup, dünyanın birçok bölgesinde yetiştirilmektedir. Steviol glikozitlerin varlığından kaynaklanan tatlılığıyla ünlüdür; 1
Steviosid, stevia bitkisinden elde edilen doğal bir tatlveırıcıdır. Yüksek tatlılık yoğunluğu ve düşük kalori içeriğine sahiptir, bu da diyabetliler ve karbonhidrat kontrollü diyetler için cazip hale getirir. Ancak, stevios
Highlight: In chronic HBV infection elevated ROS production is associated to high DNA damage in HBV-specific CD8 T cells - Response to DNA damage is dysfunctional - Up-regulation of CD38 ve persistent activatio
In the pass decades days, the Open AI ve the amazing founder behind AI application both captured attention world widely. But recently, as MIT Technology Review reported, the OpenAI CEO Sam Altman has turned ou
NMNH, NAD+'yı güçlü bir şekilde artırır ve glikolizi, TCA döngüsünü ve hücre büyümesini baskılar NAD+ is essential for biological processes such as metabolism ve DNA repair, ve its decline is associated with age-related diseas
Ginsenozids on Cancer ve Related Clinical Studies Cancer is a leading cause of death globally, ve its treatment often involves a combination of surgery, chemotherapy, ve radiation therapy. These treatm
Redoks kofaktör rejenerasyonu manipülasyonuyla büyümeye bağlı enzim mühendisliği An increasingly wide range of chemicals are now being produced from renewable feedstocks through biotechnological means. Biopro
Supervision Policies for NMN in Japan, China, America, Australia ve Canada The mainstream researches of NMN have been conducted since a decade years ago. The United States had already carried out its commerciali
Collections of Clinical Trails on NMN Oral Administation NMN, as one of NAD+ booster family critical members, become increasingly popular on the market in the filed of health pomoting. And to date, there are
Dünya genelinde salgın kontrol politikalarının gevşemesiyle birlikte, Çin, Hindistan, Malezya, Japonya ve Singapur'daki sakinler çeşitli derecelerde ilaç sıkıntısı yaşamaktadır. Ama öte yvean, ilaç türleri
Attention! The Cambridge University Researchers Found Ursodeoxycholic Acid (UDCA) Can Prevent ve Treat Covid-19 The International academic journal Nature published an article titled FXR inhibition may protect from SARS
10 Ağustos 2021'de Şanghay Bilim ve Teknoloji Üniversitesi'nden araştırmacılar, NAD+ takviyesi, kusurlu TUBBY aracılı NAMPT transkripini kurtararak tümör öldürme fonksiyonunu güçlendirir başlıklı bir makale yayımladı
